Table 2 Role of different exosomal microRNA in glioma

miR-301a

Serum of glioma patients

TCEAL7

Migration of β-catenin from cytoplasm to the nucleus was impeded by TCEAL7 which resulted in regulation of Wnt/β-catenin pathway and so TCEAL7 could be tumor suppressor in GMB

up

[67]

miR-151a

GBM patients

XRCC4

Decreasing the amount of XRCC4, postponing the clearance of DSB and increase the sensitivity of cells to TMZ was induced by miR-151a

up

[68]

miR-1238

Human tissue samples

(GBM specimens)

CAV1

Absence of miR-1238 can increase sensitivity of resistant GBM cells through CAV1/EGFR pathway

up

[71]

mir-5096

Human microvascular endothelial cells (HMEC) & Glioblastoma cells U87-U251

Kir4.1, AQP-4

In gliomas, miR-5096 was found to be downregulated

down

[73]

miR-148a

Human glioblastoma cell line T98G

CADM1

STAT3 signaling pathway was activated by miR-148a through targeting CADM1 and stimulates proliferation and metastasis

down

[77]

miR-29a

10-week-old male C57BL/6 mice/

Myeloid-derived suppressor cells (MDSCs)

Hbp1

In gliomas, miR-29a expression was increased

up

[78]

miR-92a

10-week-old male C57BL/6 mice/

Myeloid-derived suppressor cells (MDSCs)

Prkar1a

Up regulations of miR-92a was seen in gliomas

up

[78]

miR-133b

Human brain tissues (Normal & glioma)

EZH2

EZH2 and the Wnt/β-catenin signaling pathway inhibiting by miR-133b which lead to suppression of proliferation, invasion, and migration

down

[201]

miR-199a

Human brain tissues (Normal & glioma)

AGAP2

miR-199a decreased expression of AGAP2which lead to suppressing of glioma development

down

[202]

miRNA-584-5p

U87 human glioma cells

CYP2J2

miRNA-584-5p lessen the growth and intrusion of glioma cells

up

[203]

miR-9

Glioma patient specimens &

glioma cell lines

COL18A1, THBS2,

PTCH1 and PHD3

angiogenesis was elevated by miR-9

up

[204]

miR-10a and miR-21

glioma patients

RORA, PTEN

expression of miR-10a and miR-21 stimulated by hypoxia in GDEs facilitates MDSC growth and activation via targeting RAR-related

orphan receptor alpha (RORA) and phosphatase and tensin homolog (PETN)

up

[205]

miR-21, miR-222

and miR-124-3p

Blood samples of glioma patients

–

Expression of miR-21, miR-222 and miR-124-3p were decreased in gliomas

up

[206]

miR-125b

Tumor samples of GBM patients

–

Regulation of miR-125b increased in gliomas

up

[207]

mir-21

Human brain endothelial cells

VEGF

in gliomas expression of mir-21 increased

up

[66]

miR-124a

Bone marrow–derived mesenchymal stem cells

FOXA2

unusual lipid build-up inside cells due to silencing of FOXA2 by miR-124a

up

[208]

miR-451, miR-21

primary human glioblastoma

c-Myc

-

up

[209, 210]

miR-221

Human umbilical vein endothelial cells (HUVECs)

–

miR-221 expression in gliomas elevated

up

[211]

miR-21, miR-103,

miR-24, and miR-125

serum and cerebrospinal fluid of glioblastoma patients

–

Expression of miR-21, miR-103, miR-24, and miR-125 in gliomas were increased

up

[212]

miR-302–367

GSCs primary cell lines TG1, TG6 and GB1

CXCR4/SDF1, SHH, cyclin D, cyclin A

and E2F1

Cells which are adjusted to GBM internalized exosomes with high levels of miR-302–367

up

[213]

miR-1290, miR-1246

patient-derived primary cells

–

Expression of miR-1290 and miR-1246 in gliomas increased

up

[214]

miR-1587

glioma-associated human mesenchymal stem cells (GA-hMSC) &

glioma stem-like cells

NCOR1

Expression of nuclear receptor

co-repressor NCOR1which is tumor suppressor reduced by miR-1587

down

[215]

miR-375

human marrow stromal cells (hMSCs)

SLC31A1

While apoptosis promoted, immigration and intrusion and proliferation are inhibited by miR-375and suppression of SLC31A1development of glioma cell impeded

down

[216]

miR-1246

CSF of GBM patients

TERF2IP

The STAT3 signaling pathway is activated by miR-1246, while the NF-B signaling pathway is inhibited

down

[217]

miR-124

GBM patients

CDK6

GBM cell movement is reduced by miR-124

down

[218]

miR-328-3p,

miR-339-5p,

miR-340-5p,

miR-485and miR-543 -3p

serum specimens of patients with glioma tumors

–

Expression of miR-328-3p, miR-339-5p, miR-340-5p, miR-485-3p, and miR-543 were increased in glioma

up

[13]

miR-182-5p,

miR-486-5p

serum specimens of patients with glioma tumors

–

down

[13]

miR-454-3p

serum and tissue samples of glioma patients

ATG12

Immigration, intrusion and autophagy are inhibited in glioma by miR-454-3p

down

[219]

miR-146b

rat model of primary brain tumor

EGFR and NF-κB

EGFR and NF-κB protein are reduced by miR-146b in 9 L glioma cells

in vitro

down

[220]

miR-301a

GBM patients

PTEN

expression of PTEN increased by miR-301a

up

[86]

miR-221

glioma patients

DNM3

expression of DNM3 increased by miR-221

up

[221]

miR-26a

tissue samples of glioma patients

PTEN

Proliferation and angiogenesis are boosted by miR-26a

up

[222]