Fig. 4
From: Noncoding RNA-mediated molecular bases of chemotherapy resistance in hepatocellular carcinoma
Biological interrelation between ncRNAs and ferroptosis in HCC. Phosphatidylethanolamines (PEs) containing arachidonic acid (AA) and adrenic acid (AdA) are domination substrates that are involved in oxidation and ferroptosis. With the help of fatty acid transport protein (FATP) and fatty acid translocase (FAT), AA and AdA are absorbed via cellular membrane. long-chain acyl-CoA synthetase member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3) are responsible for the esterification and incorporation of PUFAs. Iron-dependent arachidonate lipoxygenases (ALOXs) and Fenton chemistry participate in the synthesis of phospholipid hydroperoxides (PE-AA-OOH/PE-AdA-OOH). GPX4 combats with lipid peroxidation through degrading toxic PE-AA-OOH/PE-AdA-OOH to nontoxic phospholipid alcohols (PE-AA-OH/PE-AdA-OH)