Table 1 Interplay between ncRNAs and EMT-associated resistance in HCC

MiRNAs

miR-212-3p

Down-regulation

Paclitaxel

Reduced ZEB2 level

[48]

miR-106a

Down-regulation

Gemcitabine

Reduced PDGF-D/Twist1 pathway

[49]

miR-9

Down-regulation

Cisplatin

Reduced EIF5A2-mediated EMT

[50]

miR-216a/217

Up-regulation

Sorafenib

Induced SMAD7/TGF-β & PTEN/PI3K/Akt signaling

[51]

LncRNAs

Linc-ROR

Up-regulation

Doxorubicin

Induced Twist1 level

[52]

Lnc-H19

Up-regulation

Sorafenib

Induced EMT via sponging miR-675

[53]

Lnc-POIR

Up-regulation

Sorafenib

Induced EMT via sponging miR-182-5p

[54]

Lnc-SNHG3

Up-regulation

Sorafenib

Induced EMT via miR-128/CD151 pathway

[55]

Lnc-AOC4P

Down-regulation

EMT

Reduced vimentin level

[56]

Linc-p21

Down-regulation

EMT and lung metastasis

Inhibited Notch signaling

[57]

CircRNAs

Circ_0003998

Up-regulation

Doxorubicin

Induced EIF5A2-mediated EMT via sponging miR-218-5p

[58]

CircFoxo3

Up-regulation

Adriamycin

Induced ABCCA1-mediated EMT via sponging miR-199a-5p

[59]