Table 2 Appraisal of function of MCM3AP-AS1 in animal models
From: A review on the role of MCM3AP-AS1 in the carcinogenesis and tumor progression
Tumor Type | Animal models | Results | (type of cells injected to the mice) (type of deletion and control) | References |
|---|---|---|---|---|
Hepatocellular carcinoma | 12 male BALB/c nude mice (divided into two groups (n = 6 per group)) | ∆ MCM3AP-AS1: ↓ tumor growth, ↓ tumor weight | Hep3B cells were infected with sh-MCM3AP-AS1 and sh-control | [18] |
Prostate cancer | 5 BALB/c mice | ∆ MCM3AP-AS1: ↓ tumor volumes | Cells were transfected with LV-si-MCM3AP-AS1 or LV-si-NC | [20] |
Breast cancer | BALB/c nude mice | ∆ MCM3AP-AS1: ↓ tumor volumes, ↓ tumor weight | MCF-7 cells were transfected with sh-NC, sh-MCM3AP-AS1#1 or sh-MCM3AP-AS1#1 + pcDNA3.1/CENPF | [26] |
Colorectal cancer | 10 BALB/c athymic nude mice (divided into two groups (n = 5 per group)) | ↑ MCM3AP-AS1: ↑ tumor volumes, ↑ tumor weigh | CR4 cells with overexpression of MCM3AP-AS1 and of C (mock cells) | [23] |
10 male BALB/c nude mice (divided into two groups (n = 5 per group)) | ∆ MCM3AP-AS1: ↓ tumor growth, ↓ tumor weight | LoVo cells were transfected with sh‐MCM3AP‐AS1 or sh‐Ctrl lentiviral vector | [25] | |
Papillary thyroid cancer | 10 BALB/c nude mice (divided into two groups (n = 5 per group)) | ↑ MCM3AP-AS1: ↑ tumor volume | TPC-1 cells were transfected with lentivirus mediated sh- MCM3AP-AS1 and sh-NC | [29] |
Lymphoma | 24 male BALB/c nude mice (divided into four groups n = 6 per group: (Daudi-siNC, Daudi-siMCM, Namalwa-siNC and Namalwa-siMCM)) | ∆ MCM3AP-AS1: ↓ tumor growth | Daudi and Namalwa cells were transfected with siNC or siMCM3AP-AS1 | [30] |
Pancreatic cancer | 24 BALB/c nude mice (divided into two groups (n = 12 per group)) | ∆ MCM3AP-AS1: ↓ tumor volumes, ↓ tumor weight, ↓ tumor growth | BxPC-3 cells were transfected with shRNA-NC and MCM3AP-AS1 shRNA-2# | [33] |
Clear cell renal cell carcinoma | 20 BALB/C nude mice (divided into two groups (n = 10 per group)) | ∆ MCM3AP-AS1: ↓ tumor volumes, ↓ tumor weight, ↓ angiogenesis | ccRCC cells expressing sh-MCM3AP-AS1 expression or the relevant NC | [35] |
Glioblastoma | male BALB/c athymic nude mice | ∆ MCM3AP-AS1 + ↑ miR-211: ↓ angiogenesis | GECs were transfected with sh-MCM3AP-AS1, pre-miR-211, sh-MCM3AP-AS1 + pre-miR-211 and control | [36] |
Lung cancer | 10 male BALB/c nude mice (divided into two groups (n = 5 per group)) | ↑ MCM3AP-AS1: ↑ metastasis | A549 cells with overexpression of MCM3AP-AS1 and NC | [40] |