Table 2 Crosstalk between LncRNAs and DNA methylation of cancer-related genes in gastric cancer
From: Regulatory function of DNA methylation mediated lncRNAs in gastric cancer
LncRNA | Gene | Pattern | Expression level | Mechanism | Outcomes |
|---|---|---|---|---|---|
HOTTIP | HOXA13 | Hypermethylation | High level | HOXA13-HOTTIP-IGFBP3 axis/p53 | Migration, invasion, prognosis |
AK058003 | SNCG | Hypermethylation | High level | Hypoxia-AK058003-SNCG axis | Migration, invasion |
AK123702 | EGFR | Hypermethylation | ↑ | Hypoxia-AK123702-EGFR axis | Migration, invasion |
ANRIL | PLZF | Hypermethylation | ↓ | EMT | Differentiation, invasion, metastasis, prognosis |
LUCAT1 | CXXC4 | Hypermethylation | ↓ | Wnt/β-catenin | Proliferation, migration, invasion |
SNHG3 | MED18 | Hypermethylation | ↓ | SNHG3/EZH2-MED18 signaling | Proliferation, migration, invasion, apoptosis |
NMRAL2P | ACOT7 | Hypermethylation | ↓ | - | Proliferation, migration, invasion, apoptosis |
HOTAIR | PCDH10 | Hypermethylation | ↓ | - | Progression, prognosis |