Fig. 2

LncRNAs and Post-transcriptional regulation in BrCSCs. a LncRNAs inhibit the initiation factor that involved in RNA translation such as elF4G which decreases the level of cyclin-dependent kinase inhibitor and promote cell proliferation. b Due to lncRNA PVT1 binding to KLF5 and promoting its stability through BAP1, beta-catenin signaling is accelerated, resulting in an increase in the development of beta-catenin tumors in BC patients. c LncRNA MT1JP suppression enhances miRNA-214 gene transcription through altering the miRNA-214/RUNX3 Axis, which results in Bim expression defect and suppresses the apoptosis process. d lncRNA treRNA forms complexes with ribonucleoproteins (RNPs) that inhibit E-cadherin translation by targeting eIF4G1 and increase the expression of EMT genes, resulting in increased cell migration and invasion