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Fig. 1 | Cancer Cell International

Fig. 1

From: STAT3-mediated upregulation of LINC00520 contributed to temozolomide chemoresistance in glioblastoma by interacting with RNA-binding protein LIN28B

Fig. 1

The expression of LINC00520 was increased in TMZ-resistant cells and its silencing improved TMZ chemoresistance in GBM. A The expression of LINC00520 in primary and recurrent GBM tissues was detected by FISH. B The expression levels of LINC00520 in TMZ-sensitive and TMZ-resistant cells were detected by qRT-PCR assay. C The efficiency of LINC00520 knockdown in U251/TMZ and SKMG-1/TMZ cells was detected after transfecting with siRNA for LINC00520. D LINC00520 knockdown decreased the cell viability of U251/TMZ and SKMG-1/TMZ under TMZ treatment (200 µM). E LINC00520 knockdown suppressed colony formation of U251/TMZ and SKMG-1/TMZ under TMZ treatment (200 µM). The effect of LINC00520 knockdown on cell apoptosis of U251/TMZ and SKMG-1/TMZ was investigated by flow cytometry (F) and TUNEL assay (G), respectively. H The distribution of cell cycle in U251/TMZ and SKMG-1/TMZ cells transfected with si-LINC00520 or si-NC were analyzed using flow cytometer

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Cancer Cell International

ISSN: 1475-2867

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