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Fig. 4 | Cancer Cell International

Fig. 4

From: STAT3-mediated upregulation of LINC00520 contributed to temozolomide chemoresistance in glioblastoma by interacting with RNA-binding protein LIN28B

Fig. 4

LINC00520 contributed to TMZ chemoresistance by interacting with LIN28B. A LIN28B was overexpressed in recurrent GBM samples compared to primary GBM samples. B RNA immunoprecipitation assay revealed that LINC00520 was markedly enriched in both TMZ-sensitive and TMZ-resistant cells using anti-LIN28B antibody, suggesting an interaction between LINC00520 and LIN28B. qRT-PCR (C) and Western blot assay (D) consistently demonstrated that the expression of LIN28B was positively related to LINC00520 expression in GBM cells

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Cancer Cell International

ISSN: 1475-2867

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