Fig. 6

Silencing of LINC00520 improved the response to TMZ chemotherapy in vivo. A Representative images of intracranial xenografts originated from U251/TMZ cells transfected with si-LINC00520 vector or si-NC vector under TMZ treatment. B The volume of tumor xenografts were evidently reduced by transfecting with si-LINC00520, suggesting that silencing of LINC00520 improve TMZ chemoresistance of GBM cells in vivo