Fig. 1
From: Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
Myricetin regulatory influence on several cellular pathways. Myricetin modulates essential cellular pathways that support cell survival, growth, proliferation, cell cycle division, and apoptosis. PI3K/Akt and RAF/MEK/ERK signaling cascades are mainly influenced by myricetin action. Further, it acts as a negative modulator of the NFkB pathway, either by directly acting on it or by promoting signaling through the Nrf2 pathway. It also blocks JAK/STAT pathway. Myricetin also interacts with cell surface receptors of the RTKs family. It directly interacts with the TGF receptor and hinders TGF signaling. It also has a role in preventing beta-catenin accumulation in the cytoplasm by activating GSK 3b. Furthermore, it also turns on the hippo pathway by promoting LATS activity directly or through JNK. Myricetin's pro-apoptotic function is also known. It promotes Bax mitochondrial translocation through p53 activation or via Akt pathway inhibition