Nanobodies; new molecular instruments with special specifications for targeting, diagnosis and treatment of triple-negative breast cancer

Table 1 List of Nanobodies against TNBC antigens

Name	Type of antigen	Sample	Binding affinity (Kd)	Refs.
Anti-TNF-VHH	TNFα	Cell line	2.05 nM	[2]
RGD4C- VHH	TNFα	Cell line, mouse model	0.1062 nM	[1]
7D12 Nb	EGFR	Cell line, mouse model	5 nM	[20]
E_VDR_L	EGFR	Mouse model	0.5 µM	[23]
Anti-CD3 epsilon nanobody	CD3	Mouse model	N.A	[26]
Anti-CD3 epsilon nanobody	CD3	Mouse model	N.A	[27]
CTLA-4 Nb16	CTLA-4	Cell line	N.A	[29]
Anti-STAT3 B VHH13	STAT3	Cell line, mouse model	22 nM	[31]
Nb8 Nb9	AKT2	Cell line	118 nM 0.5 nM	[37]
RH12	RHO protein	Tissue	1.52 nM	[38]
NJB2	FN-EIIIB in the ECM	Mouse model	2.25 nM	[44]
CAPNb2	CapG	Cell line	23 nM	[47]
CAIX1 Nb CAIX4 Nb	CAIX	Cell line, mouse model	6 nM 2 nM	[48]

ISSN: 1475-2867