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Fig. 3 | Cancer Cell International

Fig. 3

From: Nectin-4 promotes osteosarcoma progression and metastasis through activating PI3K/AKT/NF-κB signaling by down-regulation of miR-520c-3p

Fig. 3

The function of Nectin-4 on human OS cells migration and invasion. A The migration ability of the MG63 and U2OS cells with lenti-Nectin-4 or lenti-Vector-NC infection assessed using transwell assay without Matrigel (scale bars 500 μm, magnifications of 100 ×). B The invasion ability of MG63 and U2OS cells in Vector-NC group and Nectin-4-OE group via transwell assay with Matrigel (scale bars 500 μm, magnifications of 100×). C The migration and invasion abilities of the 143B cells in shCtrl group and shNectin-4#2 group via transwell assay with or without Matrigel (scale bars 500 μm, magnifications of 100×). D A wound healing assay was performed to measure the migration capacity of the MG63, U2OS cells (in Nectin-4-OE group and Vector-NC group), and 143B (in shNectin-4#2 group and shCtrl group), respectively (scale bars 100 μm, magnifications of 40×). Each assay was repeated at least three times. ns, no significance; *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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