Table 3 Clinical trials investigating positive roles of exercise training in colorectal cancer
From: Exercise and colorectal cancer: prevention and molecular mechanisms
Cancer type | Sample size | Exercise intervention | Goals | status | number |
|---|---|---|---|---|---|
Colon Cancer Rectal Cancer | 134 patients who have completed treatment for colorectal cancer in the past 2Â years 18 Years and older | Moderate-intensity physical activity | The efficacy of the physical activity intervention on fitness, vigor, fatigue, physical functioning, and body esteem | Completed | NCT00230646 |
Colorectal cancer | 207 participants 50 Years to 80 Years | Participants will read 10 behavioral messages about colon cancer screening and physical activity | Design messages which can help people learn more about how to prevent colon cancer | Completed | NCT00924690 |
Colorectal Cancer Obesity | 40 participants 50 Years and older Body mass index 25–40 kg/m2 | Physical Activity and Energy Restriction | Studying diet and physical activity in healthy overweight, obese, or inactive participants at risk of developing colorectal cancer | Completed | NCT00653484 |
Colorectal Cancer | 202 participants 40 Years to 75 Years | 60 min/session of aerobic exercise, 6 d/week at 50–50% HHR. All sessions will begin with 10 min of stretching and 5 min of warm-up, and will end with 5 min of cool down | Investigate the efficacy of a one-year moderate intensity aerobic exercise program in modulating these processes to a pattern considered low risk for colon cancer Investigate the mechanisms whereby exercise may lower colon cancer risk in humans | Completed | NCT00668161 |
Colorectal Cancer | 39 participants 18 Years and older | Patient allocated to the InterWalk-group will be introduced to the InterWalk app, including instructions on how to down load and use the application. and prescribed to perform Interval Walking for 150Â min per week | Investigate interval-walking, delivered by the InterWalk smart phone application as exercise-modality in patients with colorectal cancer | Completed | NCT02403024 |
Colorectal Cancer | 36 participants 60 Years and older | The intervention is a workbook that coaches participants through walking regularly at a safe, comfortable pace with the ultimate goal of walking at least 30Â min a day five days a week | Evaluate the effects of physical activity intervention on fatigue and quality of life during chemotherapy for CRC patients | Completed | NCT02191969 |
Colorectal Cancer Depression Fatigue Pain | 50 participants up to 120 Years | 150 min/wk of moderate exercise through use of the Curves® centers, engage in physical activity outside of Curves®, and use pedometers to track activity | Studies how well exercise, diet, and counseling work in improving physical activity and weight loss in overweight women who are breast and colorectal cancer survivors | Completed | NCT01453452 |
Anxiety Disorder Colorectal Cancer Depression | 45 participants 18 Years and older | Moderate Physical Activity | Studying how well physical activity helps patients with stage II or stage III colorectal cancer recover from cancer | Completed | NCT00373022 |
Colorectal Cancer | 50 participants 40 Years to 80 Years | The patients will perform increasing volumes of moderate intensity endurance (e.g. walking, cycling) exercise, leading up to 18 MET-hours per week by the end of three months. Patients will then maintain this activity level for the remaining 9Â months, with reduced supervision | to determine the feasibility of a one year exercise training program in post-surgical patients with colorectal cancer | Completed | NCT01991847 |
Colorectal Carcinoma | 11 participants 70 Years and older | Participants will complete the High-Intensity Functional Exercise (HIFE) programme. The programme improves lower-limb strength, balance and mobility and all the exercises can be performed by the individual at home and with minimal equipment | The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surgery | Completed | NCT03064308 |
Colorectal Carcinoma | 16 participants 18 Years and older | The exercise regime consists of 10 sessions of exercise against a constant load, each lasting 60Â s, separated by 60Â s of recovery eliciting 90% maximal heart rate. The 6 sessions are held over a 2Â week period | To determine clinical and biological effects of a preoperative exercise programme in colorectal tumour and skeletal muscle tissues | Completed | NCT02056691 |
Colorectal Cancer | 50 participants 18 Years and older | motivational counseling to exercise a minimum 18 metabolic hours per week | To evaluate compliance at 6Â months with post-treatment recommendations for a minimum of 18 metabolic units of physical activity each week in patients who have completed therapy for stage 2 and stage 3 colorectal cancer | Completed | NCT00977613 |
Colorectal Cancer | 24 participants 18 Years and older | A 2–4 week low volume, moderate intensity, supervised, one to one, individualised exercise programme | To determine whether a defined exercise programme can improve recovery and reduce complications after surgery | Completed | NCT02264496 |
Colorectal Cancer | 44 participants 18 Years and older | Aerobic exercise | To identify the dose–response effects of aerobic exercise on molecular and cellular pathways associated with physical activity and CC outcomes among patients with stage II and III CRC | Completed | NCT02250053 |
Colorectal Cancer | 788 participants 18 Years and older | 12 supervised exercise sessions over 3Â months and six supportive behavior change workshops | Investigating the feasibility of a behavior change intervention based on Self-Determination Theory in people recovering from colorectal cancer and its effects on behavior change 6Â months post-intervention | Completed | NCT02751892 |
Colorectal Cancer | 52 participants 18 Years and older | The exercise group will perform supervised stationary cycle ergometer exercise 3 times per week for 12Â weeks and be progressed from 15 to 45Â min and 60% to 110% of the power output obtained at V02peak. Resistance training will be completed twice per week and will include exercises for all major muscle groups. The training will progress from 60 to 80% of 1RM over the course of the intervention | investigate hypothesize that an exercise training program will be a safe, feasible, and effective intervention to improve the fitness and body composition of a group of colon cancer survivors | Completed | NCT00813540 |
Colorectal Cancer | 35 participants 18 Years and older | Exercise Training | Does Short-term Exercise Intervention Improve Pre-operative Physical Fitness Following Neoadjuvant Chemoradiotherapy in Colorectal Cancer Patients? | Completed | NCT01325909 |
Bladder Cancer Breast Cancer Colorectal Cancer Esophageal Cancer Fatigue Lung Cancer Lymphoma Ovarian Cancer Prostate Cancer | 49 participants 60 Years and older | Pelvic floor muscle training for one month (2 ~ 3 times a week, for 4 weeks) just one month before the stoma closure | Patients undergo resistance exercise via negative-eccentric work (RENEW), using a special seated stationary leg exercise machine, 3 times a week for up to 12 weeks | Completed | NCT00335491 |
Colorectal Cancer | 27 participants 21 Years and older | International physical activity questionnaire | To quantitatively assess the average amount of physical activity that patients are capable to perform while receiving regorafenib for the treatment of metastatic colorectal cancer | Completed | NCT02347852 |
Colorectal Cancer | 35 participants 18 Years and older | Yoga | to determine if individuals with colorectal cancer enjoy yoga and to begin to assess whether yoga is effective in improving attention and immune function in individuals with colorectal cancer compared to physical activity and usual care | Completed | NCT02564835 |
Colon Cancer Rectal Cancer Frailty | 48 participants 18 Years and older | A minimum of four weeks of prehabilitation with exercise three times a week, protein and vitamin supplements, dietitian consultation and medical optimization prior to surgery | Effects of Multimodal Prehabilitation in Colorectal Cancer Patients | Recruiting | NCT04167436 |
Colorectal Cancer Depression Fatigue Psychosocial Effects of Cancer and Its Treatment Sleep Disorders | 962 participants 18 Years and older | 3 phases Phase 1: Intensive intervention for 6 months Phase 2: Reduced intervention for months 6–12 Phase 3: Minimal intervention for months 12–36 | This randomized phase III trial is studying a physical activity program given together with health education materials to see how well it works compared with giving health education materials alone for patients who have undergone treatment for high-risk stage II or stage III colon cancer | Recruiting | NCT00819208 |
Colorectal Cancer Surgery | 500 participants Child, Adult, Older Adult | Exercise therapy during at least 2Â weeks | whether prehabilitation is cost-effective in colorectal cancer surgery among individual patients aged 70Â years and above or patients with an American Society of Anesthesiologists (ASA) score of III. We also aim to identify factors facilitating or impairing implementation of prehabilitation such that it is cost-effective | Recruiting | NCT04097795 |
Colorectal Cancer | 30 participants 19 Years to 75 Years | Participants will be instructed to complete four, high-intensity interval training workouts per week at home, for the duration of the 12-week trial | provide us with preliminary evidence for a larger trial aimed to compare the effectiveness of these two different types of home-based exercise programs on physical outcomes linked with survival, quality of life, and surrogate blood markers of colorectal cancer recurrence | Recruiting | NCT04080414 |
Colorectal Cancer | 70 participants 18 Years and older | Trimodal prehabilitation application in the form of control with the 6-min walking test and podometer of physical activity | To investigate the effects of physical activity on morbidity and mortality and in addition to postoperative recovery | Recruiting | NCT03543514 |
Colorectal Cancer | 80 participants 18 Years and older | Physical activity | how the physical activity level before operation of colon cancer affects the outcome of complication and histology | Recruiting | NCT03947840 |
Colorectal Cancer | 15 participants 50 Years to 90 Years | 30-min of moderate-intensity aerobic exercise | evaluate whether adding the exercise serum to colon cancer cells in a dish can reduce the growth of the cells compared to the resting serum | Recruiting | NCT04057274 |
Colorectal Cancer | 300 participants 18 Years to 80 Years | 12-week structured physical activity program | to assess whether a structured physical activity program (PA) during palliative chemotherapy improves progression-free survival (PFS) and/or patient-reported outcomes (ESAS-r) in patients with metastatic colorectal cancer | Recruiting | NCT02597075 |
Colorectal Cancer | 300 participants 18 Years and older | Endurance exercise | investigate the efficacy of endurance exercise following adjuvant chemotherapy in patients with colorectal cancer | Recruiting | NCT03822572 |
Colorectal Cancer | 72 participants 18 Years and older | Graduated walking programme, strengthening exercises and respiratory muscle training | the effect of home-based prehabilitation on the cardiorespiratory fitness of high-risk colorectal cancer patients awaiting surgery | Active, not recruiting | NCT03336229 |
Colorectal Cancer Rectal Cancer | 48 CRC patients on chemotherapy 18 Years and older | Physical activity tracker wristband and daily text messages delivered to the participants' phones | Determine the feasibility of the intervention via adherence and attrition, and determine the acceptability of the intervention via questionnaires and semi-structured interviews Estimate the effect of the intervention vs. usual care on physical activity, QOL, and symptoms at 12-weeks Explore the impact of the intervention vs. usual care on fitness, weight, waist circumference, and blood pressure at 12-weeks | Active, not recruiting | NCT03524716 |