Fig. 1

In silico TCGA analysis reveals differential LY6G6D expression in mucinous versus non-mucinous CRCs. A Quantification of LY6G6D mRNA in patient-matched tumor-normal mucosa extracted from The Cancer Genome Atlas (TCGA). B Left panel, the box plot shows LY6G6D mRNA expression levels in mucinous versus classical adenocarcinomas. Right panel, LY6G6D expression profile across classical adenocarcinomas and mucinous variants using for comparison Tubular Adenomas *p ≤ 0.05; t test Welch-corrected. C Heatmap of differentially expressed genes in mucinous versus Adenocarcinomas in CRC. D Upper panel, number of up and down-regulated genes in CRC according to the primary tumor location. Lower panel, shared up and down-regulated genes in both cancers. COAD colon adenocarcinoma, READ rectal adenocarcinoma