Fig. 2

A down-regulated gene signature alters the secretome-based immune responses in mucinous CRC. A Over representation of the analysis of shared up-regulated genes in Mucinous COAD and READ. B bioinformatics prediction shows that shared down-regulated genes in Mucinous include a number of secreted proteins, often selectively up-regulated in CRC at protein (red square) and mRNA level (black square). C IHC images of ISM2 labeling in normal, mucinous and classical CRC adenocarcinoma. D IHC staining profiling of ISM2 (isthmin-like protein 1) across different cancers derived from human proteome atlas database. ECS extracellular space