Fig. 1

A schematic diagram of the telomerase remedial procedures. Various telomerase-based remedial strategies have been detected: A Suppressing telomerase via binding small molecules or oligonucleotides to TERT; B Weakening POT1 binding through attaching nucleoside analogues into lately created telomeres; C interfering with telomerase localization via Shelterin and TCAB1; D Attenuating the segregation of TRF1 from telomeres by Tankyrase suppressors; E Disrupting telomerase function via G-quadruplex stabilizers; F Targeting TERT transcription; G Transforming pro-drugs to active cytotoxic particles via gene therapy; H Specifically lysing tumor target cells via oncolytic viruses; I Stimulating immune responses against hTERT expressing tumor cells through telomerase peptide or DNA vaccines [31, 32]