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Fig. 3 | Cancer Cell International

Fig. 3

From: Hormonal regulation of telomerase activity and hTERT expression in steroid-regulated tissues and cancer

Fig. 3

A schematic representation of the crosstalk between hTERT expression and various signaling pathways in cancer cells. Accumulating findings have demonstrated that telomerase could play a crucial role in unlimited proliferation and cellular immortality in various human tumor cells. Telomerase function could be modulated through several intracellular signaling cascades containing MAPK/ERK, PI3K/AKT/mTOR, Wnt/β-Catenin, and NFκB that mostly contribute to inflammation, EMT, cancer cell invasion, and metastasis [166]

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Cancer Cell International

ISSN: 1475-2867

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