Fig. 2

Frequency distribution of MATH scores among PTC patients. The MATH score represents a percentage measure of the level of intra-tumor heterogeneity and was calculated for each tumor as described in Material and Methods. A MATH values are displayed along the horizontal axis and the number of patients (frequency) with MATH within the specific ranges is displayed on the vertical axis. B Boxplots show the MATH scores distribution in different tumor stages of PTC. Boxplots show the MATH scores distribution in different PTC histological types (Classical/Usual, Follicular, Tall Cell) in C low-MATH and D high-MATH patients’ groups. E Kaplan–Meier survival curves in the low-MATH group according to tumor stage; F Kaplan–Meier survival curves in the high-MATH group according to tumor stage. MATH mutant allele tumor heterogeneity; PTC papillary thyroid carcinoma