Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma

Table 4 Relationship of clinical variables with progression free survival (PFS) by univariate Cox proportional hazards analysis in low-MATH group

Variables	Stage 1			Stage 2			Stage 3			Stage 4
	P-value Log-rank test	Univariate Cox analysis		P-value Log-rank test	Univariate Cox analysis		P-value Log-rank test	Univariate Cox analysis		P-value Log-rank test	Univariate Cox analysis
	P-value Log-rank test	HR (95% CI)	P-value Wald Test	P-value Log-rank test	HR (95% CI)	P-value Wald Test	P-value Log-rank test	HR (95% CI)	P-value Wald Test	P-value Log-rank test	HR (95% CI)	P-value Wald Test
M stage	0.7			0.07			0.6			0.02
M1 vs M0		–	–		6.3 (0.56–70.91)	0.14		–	–		14.38 (1.12–185.41)	0.04
MX vs M0		1.26 (0.36–4.36)	0.71		0 (0–Inf)	1		0.68 (0.16–2.79)	0.59		2.14 (0.19–23.61)	0.54
Primary neoplasm focus type	0.8			0.9			0.9			0.007
Unifocal vs multifocal		0.88 (0.25–3.12)	0.84		1.18 (0.11–13.12)	0.89		0.95 (0.25–3.6)	0.93		NA	NA
Neoplasm length	0.6			0.07			0.4			0.01
High vs low		1.53 (0.36–6.41)	0.56		0 (0–Inf)	1		1.91 (0.47–7.71)	0.36		NA	NA

Statistical significance of differences between Kaplan–Meier survival curves was assessed by Log-rank test. Statistical relevance as prognostic value was assessed by Wald test

ISSN: 1475-2867