Fig. 7

ITGAL promotes the growth of human AML cells. The mRNA (A) and protein (B) of ITGAL detection in MOLM13 cells transduced with sh-NC or sh-ITGAL. C Cell growth assays in MOLM13 cells. D Representative pictures of colonies from MOLM13 cells. E Representative flow cytometry plots of the percentage of apoptotic cells in MOLM13 cells with sh-NC or sh-ITGAL. L: living cells; EA: early apoptosis; LAL: late apoptosis. F Kaplan–Meier survival curves of NOD mice injected with MOLM13 cells transduced with sh-NC or sh-ITGAL. G The percentages of CD45+ cells in recipient mice. H The possible role of ITGAL in the AML progression, drawn by Figdraw. This diagram is largely based on pure bioinformatics analyses, which need to be validated using wet-lab experiments