Fig. 2
Potential role of ferroptosis in immunotherapy. CD8+ T cells release IFNγ, activate JAK-STAT1 pathway, down-regulate SLC3A2 and SLC7A11, and reduce cystine uptake by cancer cells, resulting in cell ferroptosis. Cys, cysteine; Cys2, cystine; DAMPs, damage-associated molecular patterns; GPX4, glutathione peroxidase-4; GSH, glutathione; ICD, immunogenic cell death; IFN γ, interferon γ; JAK, janus kinase; PD-1, programmed death-1; PD-L1, programmed death-ligand 1; Se, selenium; SLC3A2, solute carrier family 3 member 2; SLC7A11, solute carrier family 7 member 11; STAT1, signal transducer and activator of transcription 1; System Xc−, cysteine/glutamate transport protein system