Fig. 7
From: Correlation of the prognostic value of FNDC4 in glioblastoma with macrophage polarization
Effect of exogenous FNDC4 on polarization of M0 macrophages. a. Analysis of FNDC4 promoting polarization of M0 macrophages towards M1 direction: Compared with M0, the CD80/CD206 ratio of M0 + LPS was significantly increased. Compared with M0 + FNDC4, the CD80/CD206 ratio of M0 + LPS + FNDC4 was also significantly increased. However, compared with M0 + LPS, the CD80/CD206 of M0 + LPS + FNDC4 decreased significantly. b. Analysis of FNDC4 promoting polarization of M0 macrophages towards M2 direction: Compared with M0, the CD80/CD206 ratio of M0 + IL-4 was significantly increased. Compared with M0 + FNDC4, the CD80/CD206 ratio of M0 + IL-4 + FNDC4 was also significantly increased. However, compared with M0 + IL-4, the CD80/CD206 of M0 + IL-4 + FNDC4 has barely changed. (Data are presented as mean ± SE; “***” represents p value less than 0.001; “****” represents a p value less than 0.0001)