A review on the role of LINC01133 in cancers

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Taheri, Mohammad; Mokhtari, Majid

doi:10.1186/s12935-022-02690-z

Cancer Cell International

Table 2 Function of LINC01133 in animal models

From: A review on the role of LINC01133 in cancers

Tumor/disorder type	Animal models	Results	References
Gastric cancer	Immunodeficient BABL/c female nude mice	↑ LINC01133: ↓ GC progression and ↓ metastasis	[21]
Gastric cancer	Tumor-bearing nude mice	↑ LINC01133: ↓ tumor growth	[22]
Epithelial ovarian cancer	Female athymic BALB/c nude mice	↑ LINC01133: ↑ metastasis	[14]
Ovarian cancer	Female BALB/c nude mice	∆ LINC01133: ↑ tumor weight, ↑ tumor volume, ↑ metastasis	[15]
Hepatocellular carcinoma	Female BALB/c nude mice	∆ LINC01133: ↓ tumor weight, ↓ PI3K/AKT signaling activity	[23]
Hepatocellular carcinoma	Male BALB/c nu/nu mice	↑ LINC01133: ↑ tumor volume, ↑ metastasis	[19]
Breast cancer	Female nude mice	∆ LINC01133: ↑ metastasis	[25]
Nasopharyngeal carcinoma	Immunodeficient male BALB/c nude mice	↑ LINC01133: ↓ metastasis	[26]
Renal cell carcinoma	Female nude BALB/7 mice	∆ LINC01133: ↓ tumor weight, ↓ tumor volume	[27]
Pancreatic cancer	BALB/c nude mice	∆ LINC01133: ↓ tumor weight, ↓ proliferation	[29]
	Male BALB/c-nu nude mice	↑ LINC01133: ↑ tumor weight, ↑ metastasis ∆ LINC01133: ↓ tumor weight, ↓ metastasis	[18]
	SCID mice	↑ miR-216a -5p (a target of LINC01133): ↓ tumor weight, ↓ metastasis	[30]
	Male immunodeficient BALB/c nude mice	∆ LINC01133: ↓ tumor growth, ↓ tumor weight and ↓ tumor volume	[31]
Colorectal cancer	Male NOD–SCID–gamma mice	∆ LINC01133: ↑ metastasis	[34]
Lung cancer	Female athymic BALB/c nude mice	∆ LINC01133: ↓ tumor weight, ↓ tumor growth	[20]
Bladder cancer	Male BALB/c-nu mice	↑ LINC01133: ↓ tumor growth	[36]

∆: knock-down or deletion, GC: Gastric cancer, SCID: severe combined immunodeficient

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