Table 3 Dysregulation of LINC01133 in clinical samples

Gastric cancer

200 pairs of tumor tissues and AdNTs

Down

Longer 5-year OS and 5-year PFS

LINC01133 was found to be an independent protective predictor of OS and PFS.

Low expression levels of LINC01133 were correlated with greater size of tumor, advanced T stage, lymphatic invasion, advanced TNM stage, and infiltration of peritumoral tissues.

[21]

GEO database (GSE70880, GSE51308, GSE84787, GSE50710, GSE79973, GSE19826, GSE54129) plus 50 pairs of tumor tissues and AdNTs

Down

Gender (higher in females than males)

[39]

Epithelial ovarian cancer

25 EOC tissues and 4 normal ovarian surface epithelial tissue

Up

Lower OS

[14]

Ovarian cancer

GEO database (GSE14407, GSE38666, and GSE83693) plus 50 ovarian cancer tissues and 30 normal ovarian tissues

Down

Longer OS

[15]

Hepatocellular carcinoma

667 patients with primary HCC (three different cohorts)

Up

CNV in LINC01133 was associated with lower OS.

The CNV of LINC01133 was an independent prognostic factor for patient survival.

[19]

Cervical cancer

TCGA database

Up

[24]

50 pairs of tumor tissues and AdNTs, TCGA database from GEPIA

Up

Higher T stage and negative HPV infection

[16]

TCGA database

Up

[40]

115 CESC cases, 79 cases of CIN and 101 healthy controls

Up in CESC and CIN

[41]

Breast cancer

74 pairs of tumor tissues and AdNTs

Down

Longer OS

Low expression levels of LINC01133, and lymph node metastasis and TNM stage was found to be independent prognostic indicators for patients.

Down-regulation levels are associated with lymph node metastasis and advanced TNM stage.

[25]

TCGA database (derived from TANRIC database) GEO database (GSE76275, GSE76124, GSE36771, and GSE3744)

Up

Poor OS

[17]

Lnc2Cancer database 79 pairs of luminal A and B BC tissues and AdNTs

Down in luminal A and B BC tissues

[42]

Nasopharyngeal carcinoma

15 NPC tissues and 6 normal nasopharyngeal epithelium tissues GEO database (GSE12452: 31 NPC and 10 normal nasopharyngeal samples)

Down

[26]

Renal cell carcinoma

34 pairs of tumor tissues and AdNTs

Up

[27]

Pancreatic cancer

132 patients with PDAC GEO database: (GSE15471, GSE16515, and GSE32676) and

TCGA database

Up

Poor OS and DFS

Tumor size,

T stage,

TNM stage, histological grade, disease-free status, and mutation count

[29]

GEO database: (GSE15471 and GSE16515: 75 PDAC tissue samples and 55 normal pancreatic)

Up

Shorter OS

[43]

GSE32676 and GSE16515

Up

[18]

40 pairs of tumor tissues and AdNTs

Down-regulation of miR-216a -5p (a target of LINC01133)

Down-regulation levels of miR-216a -5p are associated with peripancreatic lymphatic metastasis, perineural invasion and advanced TNM stage.

[30]

32 pairs of tumor tissues and AdNTs

80 pairs of tumor tissues and AdNTs

Up

Poor OS

Higher TNM stage

[31]

Oral squamous cell carcinoma

50 pairs of tumor tissues and AdNTs

Down

Longer OS

[32]

Esophageal squamous cell carcinoma

149 pairs of tumor tissues and AdNTs

Down

Poorer OS and PFS

LINC01133 was found to be an independent favorable predictor of OS and PFS.

(LINC01133 expression Combination, TNM stage and drinking status, showed to be the best predictive value in patients.)

Low levels of LINC01133 were associated with ever smoking, ever drinking, large tumor size, greater depth of tumor invasion, lymph node metastasis, and advanced TNM stage.

[37]

Osteosarcoma

27 pairs of tumor tissues and AdNTs

Up

Lower OS and poorer prognosis

[33]

Colorectal cancer

187 pairs of tumor tissues and AdNTs

Down

Longer OS

LINC01133 was found to be an independent prognostic factor.

Low levels of LINC01133 were associated with lymph node metastasis, distant metastasis, N classification, and TNM stage.

[38]

219 pairs of tumor tissues and AdNTs GEO database: (GSE40967)

Down

Longer OS longer OS and RFS

Low levels of LINC01133 were associated with distant metastasis.

[34]

Lung cancer

GEO database: (GSE18842 and GSE19804) 68 pairs of tumor tissues and AdNTs

Up

Lower OS and poorer prognosis

Tumor size, advanced pathological stage, and lymph node metastasis

[20]

GEO database: (GSE10245)

Up in LSCC but not in LAD samples

Lower OS

[35]