Fig. 7

Inhibition of TRIM36 in vivo causes the progression of tumor growth. a and b Subcutaneous tumor formation in Huh7 xenograft tumors established via Huh7 cell line transduced with lenti-sh-NC and lenti-sh-TRIM36. c qRT–PCR showing the expression level of TRIM36 mRNA in Huh7 xenograft tumors established via Huh7 cell line transduced with lenti-sh-NC and lenti-sh-TRIM36. d Individual value plot showing the tumor volume of Huh7 xenograft tumors established via Huh7 cell line transduced with lenti-sh-NC and lenti-sh-TRIM36 at different time points (6 day, 9 day, 12 day, 15 day, 18 day, 21 day, 24 day). e Individual value plot showing the tumor weights of in Huh7 xenograft tumors established via Huh7 cell line transduced with lenti-sh-NC and lenti-sh-TRIM36. f Left panel showing the hematoxylin–eosin staining of tumor mass established via Huh7 cell line transduced with lenti-sh-NC and lenti-sh-TRIM36, and the remaining showing immunohistochemical staining of β-catenin, cleaved caspase-3, Ki-67 and TRIM36 in HCC and adjacent non-tumor tissues. Scale bars, 100 μm. The upper panel was 100 × magnification, the lower panel was 200 × magnification. P value was calculated using two-tailed unpaired Student’s t-test, error bars are means ± SD, n = 5 independent repeats. *P < 0.05, **P < 0.01