Fig. 1
From: Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy
A schematic diagram of the ING protein family members involved in chromatin remodeling. Chromatin compaction is modulated via posttranslational modifications including histone methylation (silent chromatin) as well as histone acetylation (active chromatin). By binding to the histone mark H3K4me3, ING1b recruits the HDAC mSin3A/HDAC1/2 complex or Gadd45a, for local histone deacetylation. ING2a, in complex with HDAC1/2, SAP30 and mSin3A can bind either H3K4me3 or H3K9me3. ING3 can acetylate the N-terminal tails of histones H4 and H2A. Moreover, ING4 and ING5 are in complex with MYST-HB01-JADE-hEAF6-HAT. ING5 is also a component of another HAT complex (MOZ/MORF-MYST-HAT) [14, 15]