Fig. 3
From: Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy
A schematic illustration of the ING proteins activating the p53 cascade. All members of the ING family (INGs 1–5) have been detected to associate with enhancing p53 activity via inducing its acetylation or increasing its stability. ING proteins differentially impinge upon the main tumor suppressive cascades of apoptosis, anti-proliferation, cell cycle arrest as well as senescence [32, 98, 99]