Table 1 Up/down regulation of apoptotic genes in different cancer types

FAS

Downregulation

T-cell lymphoma, colon carcinoma, neuroblastoma, melanoma, ovarian cancer

[62,63,64,65,66]

DR4/DR5

Downregulation

Medulloblastoma

[67]

CASPASE-8/10

Downregulation

Hepatocellular carcinoma, bladder, small-cell lung carcinoma, GBM, retinoblastoma, and neuroblastoma

[68,69,70,71,72]

BIM

Downregulation

Renal cell carcinoma and chronic myeloid leukemia Burkitt’s lymphoma

[73, 74]

APAF-1

Downregulation

Leukemia, melanoma, and gastric, bladder, and kidney cancer

[75,76,77,78]

XAF1

Downregulation

Gastric and bladder cancer, Prostate cancer, Pituitary adenoma, B-cell chronic lymphocyte leukemia

[79,80,81,82,83,84]

BCL-2

Downregulation

Gastric cancer, chronic lymphocytic leukemia, pancreatic, breast, colon, and kidney cancer, and Burkitt’s lymphoma

[85, 86]

BAX

Downregulation

Multiple myeloma cells, Burkitt’s lymphoma, colon cancer

[87,88,89]

BAK

Downregulation

Multiple myeloma cells, Burkitt’s lymphoma

[87, 88]

PUMA

Upregulation

Multiple myeloma cells, Burkitt’s lymphoma

[87, 88]

BAD

Upregulation

Multiple myeloma cells

[87]

Bcl-2L10

Downregulation

Gastric cancer and leukemia

[90, 91]

BIK

Downregulation

Glioma, RCC, prostate cancer, and myeloma

[92,93,94,95]

BNIP3

Downregulation

Gastric cancer, colorectal cancer, leukemia, and HCC

[96,97,98,99]

HRK

Downregulation

Colorectal, gastric, GBM, PCNSL, and prostate cancer

[100,101,102,103]

HRK

Upregulation

Lung, prostate, bladder, and ovarian cancers and GBM

[104,105,106,107,108]

MLC1

Upregulation

AML, gastric tumors, GBM, and lung cancer

[109,110,111,112]

BCL-6

Upregulation

Bladder, prostate, breast, and lung cancer and lymphoma

[113]

PUMA

CASPASE-3

Downregulation

Bladder and glioma

[114, 115]

Bcl-XL

Upregulation

Hodgkin lymphoma, AML, and ovarian cancer

[116, 117]

Bcl-2

Upregulation

Gastric cancer

[118]