Table 2 List of TRAIL pathway-specific lncRNAs along with their adopted mechanism

ST3GAL6-AS1

Down-regulated

Indirect regulation of FasL, TRAIL ligand, Bad, Bim

[141, 142]

LINC00460

Up-regulated

↓TRAIL, ↓caspase-9, ↓Bax, ↓Bcl-2

[149]

GAS5

Down-regulated

↑TRAIL l, ↑FasL, ↓miR‑182‑5p

[143, 144]

LINC00152

Down-regulated

↓Bcl-2, ↑ FasL

[146]

PCAT-1

Up-regulated

↓PARP, ↓caspase-3 cleavage, ↓Bax, ↑Bcl-2

[128]

SCARNA2

Up-regulated

↑Bcl-2, ↑EGFR expression via miR-342-p sequestering

[124]

HAGLROS

Up-regulated

↑autophagy, inhibition of extrinsic apoptotic pathway ↑ATG5

[160]

LUCAT1

Up-regulated

dgradation of p53 at protein level

[129]

ZFAS1

Up-regulated

↑p54 destabilization, ↓PARP cleavage

[131]

MAPKAPK5‐AS1

Up-regulated

Inhibition of extrinsic apoptosis via epigenetic silencing of p21

[163]

HOXA-AS2

Up-regulated

↓p21 transcription

[164]

BANCR

Down-regulated

↑ p21 translation

[165]

ATB

Up-regulated

↓p2, ↓p53 expression via regulation of miR-200c

[168]

FOXP 4‐AS1

Up-regulated

↓ p21

[166]

SNHG6

Up-regulated

epigenetic silencing of p21

[167]