Table 2 Examples of nanobodies that are currently being tested in clinical trials
From: Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy
Nanobodies compound | Clinical use | Target | Stage | References |
|---|---|---|---|---|
Caplacizumab ALX-0681 ALX-0081 | Thrombotic thrombocytopenic purpura | Ultra large von Willebrand factor | Clinical trial phase III | [129] |
ALX-0171 | Lower respiratory tract infection | RSV (respiratory syncytial virus) | Clinical trial phase I-II | [128] |
Bispecific nanobody-derived CAR-T cells | Lymphoma | CD19 CD20 | Clinical trial phase I | [182] |
[131I]-SGMIB anti-HER2 VHH1 | Breast cancer | HER2 | Ongoing | [114] |