Fig. 1

A schematic diagram of the role of several ncRNAs in triggering the Sonic Hedgehog signaling cascade in Breast Cancer. Mounting researches suggest that dysregulation of sonic hedgehog signaling pathway can play a key role in tumorigenesis in breast cancer cells. As an illustration, the recent study has detected that overexpression of lncRNA-Hh can activate Shh-GLI1 signaling and promote the expression levels of SOX2 and OCT4, thereby enhancing cancer stem cells generation in Twist-positive breast cancer cells [22]. Further experiment has validated that lncRNA LOC101930370 can significantly elevate SHH and Gli-1 expression via sponging miR-1471, therefore promoting cell proliferation and metastasis in breast cancer cells by modulating the hedgehog cascade [21]. Moreover, another research has pointed out that miR-26a has a remarkable part in suppressing breast cancer cell proliferation and invasion via downregulating the expression levels of FAM98A, SHH, SMO and GlI1, thereby inactivating the sonic hedgehog pathway in tumor cells [20]