From: Emerging role of non-coding RNAs in the regulation of Sonic Hedgehog signaling pathway
Tumor/disease type or cellular mechanisms | Animal models | Results | References |
---|---|---|---|
Acute myocardial infarction | 6–8-week-old male Sprague Dawley (SD) rats (Rat MI Model) | ∆ miR-802-5p: ↓ apoptosis after MI via activating Shh signaling pathway via targeting PTCH1, thus decreasing myocardial injury and improving heart function | [57] |
Alopecia | DP sphere xenograft to nude mice | ↑↑ XIST: ↑ DP mediated hair follicle regeneration via targeting miR-424 to promote Shh expression, thus activating hedgehog signaling | [16] |
Breast cancer | 5 weeks‐old athymic nude mice | ∆ lncRNA‐Hh: ↓ tumor growth | [22] |
Breast cancer brain metastasis | 6-week-old female BALB/c nu/nu mice | ∆ circBCBM1: ↓ tumor volumes and weights | [23] |
Cerebrovascular disease | rat cerebral ischemic injury model | miR-153 expression was decreases ↑↑ miR-153: ↓ PTC expression and ↑ activation of Shh signaling pathway and angiogenesis | [58] |
Cervical cancer | 4-week-old SPF female BALB/c nude mice | ↑↑ microRNA: ↓ tumor growth and tumor angiogenesis via targeting ZIC2 and downregulating the Hedgehog signaling pathway | [28] |
Diabetes mellitus | Sprague–Dawley male rats | miR-9 and miR-29a: ↓ activation of SHH signaling pathway via ISL1, nociception threshold and peripheral nerve conduction velocity miR-9 and miR-29a rise AR activity and disease activity by reducing ISL1 | [59] |
Glioblastoma multiforme | 5-week–old female BALB/c-nude mice | ↑↑ miR-326 combined with curcumin treatment: ↓ tumor growth | [25] |
Hepatocellular carcinoma | 4-week-old male athymic BALB/c nu/nu mice | ↑↑ TUG1: ↓ tumor growth via targeting miR-132 | [35] |
Inflammatory bowel disease | C57BL/6 wild-type (WT) and iNOS − / − mice | NOD2-iNOS/NO-miR-146a-mediated SHH Signaling is necessary for inflammatory responses | [36] |
Liver regeneration | carbon tetrachloride (CCl4)-treated rats transplanted with human CP-MSCs (Tx) or saline (non-Tx) | ↑↑ miR-125b from CP-MSCs: ↓ activation of Hh signaling, thus ↑ the reduced fibrosis | [60] |
Lung cancer | 6-week-old female BALB/C nude mice | ∆ BLACAT1: ↓ tumor growth and metastasis | [40] |
4-week-old BALB/c nude female mice | ∆ LINC01426: ↓ tumor size, volume, and weight | [41] | |
Lung fibrosis | 6-week-old female C57BL/6 mice | ↑↑ miR-193a: ↑ autophagy and ↓ PQ-induced pulmonary fibrosis Ligustrazin: ↑ autophagy and ↓ paraquat-induced pulmonary fibrosis | [42] |
Medulloblastoma | Ptch1 ± mice, C57BL/6 and PtenFloxp/Floxp mice, GFAP-Cre mice | The effects of miR-183∼96∼182 to maintain cell proliferation depends on hedgehog signaling activation | [61] |
Athymic nude mice | ↑↑ Nkx2-2as: ↓ tumor growth Gli2/FoxD1/Nkx2-2as axis was found to be involved in the pathogenesis of Shh-subtype MB | [45] | |
Neuroblastoma | 17-day-old chick embryos | ↑↑ CDON: ↓ tumor size | [47] |
Osteonecrosis of the femoral head | a rat model of GC-induced ONFH | ↑↑ miR-378-ASCs-Exos: ↑ osteogenesis via targeting Sufu to increase the Shh signaling pathway | [51] |
Osteoporosis | Wistar female rats | Levels of SUFU were upregulated bet levels of miR-874, Shh, Ptch, Smo, BMP2, Runx2, and PCNA were downregulated ↑↑ miR-874: ↑ proliferation and differentiation of via targeting SUFU and activating of Hedgehog signaling pathway | [62] |
Parkinson's disease | male specific pathogen-free C57BL/6 mice | ↑↑ miR-124: ↑ proliferation and ↓ apoptosis by downregulating EDN2 through activating the Hedgehog signaling pathway | [63] |
The transition of dividing neuroepithelial progenitors to differentiated neurons and glia | zebrafish | ∆ miR-219: ↑ growth of primary cilia via elevating Shh signaling | [64] |
Trigeminal neuralgia | rat model of CCI-IoN | Upregulation of miR-195 and downregulation of Patched1 were seen ↑↑ miR-195: ↑ facial pain development via targeting Patched1 in the Shh signaling pathway | [65] |