Table 3 Dysregulation of Shh signaling-related ncRNAs and in clinical samples

Breast cancer

13 pairs of tumor/nearby tissues

Down-regulation of miR-26a

–

–

[20]

15 pairs of tumor/nearby tissues

Down-regulation of miR-1471

–

–

[21]

Cervical cancer

87 pairs of tumor/nearby tissues

Down-regulation of miR-129-5p, and activated Hedgehog signaling pathway

–

–

[28]

Diabetes mellitus

GEO database (GSE27382

and GSE95849)

30 patients with DM

Up-regulation of miR-9 and miR-29a

Down-regulation of ISL1

–

–

[59]

Gallbladder carcinoma

68 gallbladder cancer patients and 70 healthy controls

Up-regulation of SNHG6 and down of miR-26b-5p

–

age, sex, tumor invasion, differentiation degree, tumor location, and TNM staging

[33]

Glioblastoma Multiforme

TCGA dataset with > 500 different GBM samples

Up-regulation of miR-9

–

–

[26]

Hepatocellular carcinoma

20 pairs of tumor/nearby tissues

Up-regulation of SHH and down of miR-132

–

–

[35]

Laryngeal cancer

24 pairs of tumor/nearby tissues

Down-regulation of LINC‐PINT and up of miR-425-5p

–

stemness

[37]

Lung cancer

20 pairs of tumor/neraby tissues

Up-regulation of BLACAT1

–

–

[40]

GEPIA database: 483 tumor tissues and 347 normal tissues

Up-regulation of LINC01426

–

–

[41]

Neuroblastoma

226 NB patients

Down-regulation of CDON and up-regulation of miR-181-a and miR-181-b

Poor OS

higher-staged, more aggressive tumors

[64]

Osteoarthritis

46 OA patients

Up-regulation of SHH and it signaling targets

–

–

[48]

Pancreatic cancer

23 pancreatic adenocarcinomas, 18 adjacent benign pancreatic specimens and 25 normal pancreatic specimens

Up-regulation of miR-132 and down-regulation of Shh

–

–

Retinoblastoma

10 patients with RB and 10 healthy controls

Down-regulation of miR-361-3p

–

–

[53]