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Table 2 Univariate analyses of potential prognostic factors for OS using the training cohort

From: Prognostic value of the modified systemic inflammation score in non-small-cell lung cancer with brain metastasis

Characteristics

HR (95% CI)

P value

Age(year)

  < 65

1

 

  ≥ 65

1.010(0.841–1.213)

0.913

Gender

 Male

1

 

 Female

1.038(0.868–1.242)

0.68

Smoking

 Smoker

1

 

 Never-smoker

0.811(0.669–0.984)

0.033

PS

 0–1

1

 

  ≥ 2

1.169(0.980–1.395)

0.083

Synchronous BM

 

 Yes

1

 

 No

0.919(0.752–1.123)

0.409

Maximum diameter of BM lesions

  < 2 cm

1

 

  ≥ 2 cm

1.235(1.046–1.459)

0.013

Receiving local treatment (Surgery/WBRT/SRS)

 Yes

1

 

 No

2.199(1.852–2.610)

 < 0.001

Receiving chemotherapy

 yes

1

 

 no

1.897(1.573–2.289)

 < 0.001

NLR

  ≥ 4.71

1

 

  < 4.71

0.568(0.468–0.689)

 < 0.001

Albumin

  < 40 mg/l

1

 

  ≥ 40 mg/l

0.523(0.438–0.625)

 < 0.001

  1. PS, Performance Status; BM, Brain metastases; WBRT, whole-brain radiation therapy; SRS, stereotactic radiosurgery; NLR, neutrophil–lymphocyte ratio