A review on the role of MEG8 lncRNA in human disorders

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Taheri, Mohammad; Shojaei, Seyedpouzhia

doi:10.1186/s12935-022-02705-9

Cancer Cell International

Table 1 Summary of in vitro studies about the role of MEG8 in human disorders (∆: knock-down or deletion, VSMC: vascular smooth muscle cell, OGD: oxygen-glucose deprivation)

From: A review on the role of MEG8 lncRNA in human disorders

Tumor/ disorder type	Targets/ Regulators and Signaling Pathways	Cell line	Function	References
Lung cancer	miR-107, CDK6, Rb/E2F3 pathway	BEAS-2B, A549 and H1299	↑ MEG8: ↑ proliferation, ↑ migration, ↑ invasion ∆ MEG8: ↓ cell progression	[7]
	miR-15a-5p, miR-15b-5p, PSAT1	16HBE, A549, H1299, H1975, SPC-A1, and PC-9	∆ MEG8: ↓ proliferation, ↓ migration, ↓ invasion	[8]
	miR-34a and miR-203, EZH2, SNAI1 and SNAI2	A549 and LC2/ad	MEG8 was involved in EZH2 recruitment to inhibit miR-34a and miR-203 expression. ↑ MEG8: ↑ EMT process	[9]
Pancreatic cancer	miR-34a and miR-203, EZH2, SNAI1 and SNAI2	Panc1	MEG8 was involved in EZH2 recruitment to inhibit miR-34a and miR-203 expression. ↑ MEG8: ↑ EMT process	[9]
Hemangioma	miR203, Notch signaling pathway	HemECs	∆ MEG8: ↓ proliferation, ↓ migration, ↑ apoptosis	[10]
Hemangioma	miR-497-5p, NOTCH2	HemECs	∆ MEG8: ↓ proliferation, ↑ ferroptosis	[21]
Hepatocellular carcinoma	miR-367-3p, 14-3-3ζ, TGFβR1, TGFβ signaling	Human LO2 hepatocytes and HepG2, Huh7, HCCLM3, and HMCC-97 H HCC	∆ MEG8: ↓ proliferation, ↓ migration, ↓ invasion	[11]
Bone-invasive pituitary adenomas	miR-454-3p, TNF-α	293T and RAW264.7	↑ MEG8: ↑ promoting RAW264.7 cells to destroy bone	[12]
Wilms’ tumor	miR-23a-3p, CRK	WT cells	∆ MEG8: ↓ viability, ↓ migration, ↓ invasion	[13]
Diabetic nephropathy	miR-770-5p	CIHP-1	↑ MEG8: ↑ glucose-mediated apoptosis, ↑ miR-770-5p expression by reducing the methylation of miR-770-5p	[14]
Atherosclerosis	miR-181a, PPARα	VSMCs	↑ MEG8: ↓ VSMC proliferation, ↓ migration, ↑ apoptosis	[15]
Ischemic stroke	miR-130a-5p, VEGFA	OGD-treated BMECs	∆ MEG8: ↓ viability, ↓ migration, ↓ angiogenesis	[16]
Trophoblast dysfunction and abortion		HTR-8/SVneo cell line from early villous trophoblasts (EVTs)	↑ MEG8: ↓ proliferation of trophoblast, ↓ invasion	[17]
Henoch-Schonlein purpura	miR-181a-5p, SHP2,	RMDMs from HSP rats	↑ MEG8: ↑ M1 polarization, ↓ JAK2/STAT3 pathway	[18]
Osteoarthritis	PI3K/AKT signaling pathway	IL-1β-treated C28/I2 cells	∆ MEG8: ↓ proliferation, ↓ activation of the PI3K/AKT signaling pathway, ↑ apoptosis, ↑ inflammatory response	[19]

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ISSN: 1475-2867

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