Table 2 Summary of in vivo studies about the role of MEG8 in diverse disorders (∆: knock-down or deletion)
From: A review on the role of MEG8 lncRNA in human disorders
Tumor/ disorder Type | Animal models | Results | References |
|---|---|---|---|
Lung cancer | Nude mice | ∆ MEG8: ↓ tumor growth, tumor volume, tumor weight | [8] |
Bone-invasive pituitary adenomas | Male BALB/c nude mice | ↑ MEG8: ↑ tumor volume, ↑ bone destruction | [12] |
Ischemic stroke | Male Sprague–Dawley rats | ↑ MEG8: ↓ cerebral ischemia in ischemic stroke | [16] |
Trophoblast dysfunction and abortion | Pregnant C57BL/6 female mice | MEG8 expression gradually increased during placental development. | [17] |
Henoch-Schonlein purpura | Wistar rats | Expression levels of MEG8 were much lower in HSP rats than control rats. | [18] |