Table 3 Results of studies that reported dysregulation of MEG8 in clinical samples
From: A review on the role of MEG8 lncRNA in human disorders
Tumor/ disorder type | Samples | Expression (Tumor vs. Normal) | Kaplan-Meier analysis (impact of MEG8 up-regulation) | Univariate/ Multivariate cox regression | Association of MEG8 expression with Clinicopathologic characteristics | References |
|---|---|---|---|---|---|---|
Lung cancer | 21 pairs of NSCLC tissues and ANCTs | Up | – | – | – | [7] |
37 pairs of NSCLC tissues and ANCTs | Up | – | – | – | [8] | |
Hepatocellular carcinoma | 74 pairs of NSCLC tissues and ANCTs | Up | Lower OS and DFS | – | Edmondson Steiner grading, venous infiltration, and the number of tumor nodules | [11] |
Bone-invasive pituitary adenomas | 40 pituitary adenoma patients | Up | – | – | – | [12] |
Ovarian cancer | GEO database: (GSE36668, GSE12470, GSE14407, and GSE27651), GEPIA2 and starBase database | Down | Better OS | – | – | [23] |
Colorectal cancer | 20 colorectal cancer, 20 adenomas, 20 healthy controls | Lower in colorectal cancer and adenomas than controls | – | – | – | [24] |
Giant cell tumor of bone | 5 GCTSCs and 5 MSCs | Down in GCTSCs | – | – | – | [25] |
Diabetic nephropathy | 66 DN patients 66 DM patients 66 healthy controls | Up in DN and DM than controls, Up in DN than DM | – | – | – | [14] |
Gestational diabetes mellitus | 400 pregnant females (78 females were diagnosed as GDM during pregnancy) | Up in females who showed GDM | – | – | One month before the diagnosis of GDM, plasma levels of MEG8 were sufficient to distinguish GDM patients from healthy controls. GDM females with higher level of MEG8 showed higher incidence of kidney injury. | [26] |
Trophoblast dysfunction and abortion | 20 spontaneous abortion villi in early pregnancy and 20 normal early villi | Up in spontaneous abortion villi | – | – | – | [17] |
Temple syndrome | 3 Temple syndrome patients | DNA-hypermethylation of the MEG8-DMR was observed in 3 patients. | – | – | – | [27] |
13 non-deletion TS14 patients | MEG8-DMR was hypermethylated in all patients. | – | – | – | [28] | |
Kagami-Ogata syndrome (KOS14) | 4 KOS14 patients with different deletions | MEG8-DMR was hypomethylated in patients. | – | – | – | |
Osteoarthritis | 22 OA patients and 22 healthy controls | Down | – | – | – | [19] |
Abnormal semen | 40 Semen samples from patients (8 normozoospermic, 16 asthenospermic, 3 oligospermic, 11 oligoasthenospermic and 2 morphologically deformed) | DMR of MEG8 were different in the abnormal semen groups. MEG8 DMR methylation was significantly increased in the asthenospermic group. Higher methylation levels of MEG8 DMR in the oligospermic and oligoasthenospermic groups were observed. | – | – | – | [29] |