Fig. 2
From: Recent advances and limitations of mTOR inhibitors in the treatment of cancer
Constituent proteins of mTORC1 and mTORC2. A a central signaling molecule that is the mammalian target of rapamycin (mTOR) serves as a core constituent to form a distinctive complex with other molecules DEPTOR, PRAS40, mLST8 and Raptor, resulting in the formation of the mTORC1 complex, while the B mTOR with other five proteins DEPTOR, mSin1, Mlst8, Rictor and Protor forms the mTORC2 complex. Both the distinct protein complexes regulate several cellular mechanisms