Table 1 Function of miR-1908 in cancers based on studies in cell lines (∆: knock-down or deletion)
From: miR-1908: a microRNA with diverse functions in cancers and non-malignant conditions
Tumor type | Interactions | Cell lines | Function | Exact role | References |
|---|---|---|---|---|---|
Breast cancer | ID4, LTBP4, GPM6B, RGMA, EFCAB1, ALX4, OSR1 and PPARA | MCF-10A, MCF-7, MDA-MB-231 | ↑↑ miR-1908-3p: ↑ proliferation, migration and invasion | Oncogenic | [5] |
Cervical cancer | HDAC10 | Ca-Ski, SiHa, C-4 I and End1/E6E7 | ↑↑ miR-1908: ↑ cell growth and invasion | Oncogenic | [6] |
Glioblastoma | PTEN, AKT/FOXO3a and AKT/mTOR pathways | A127, SW1783, U87, U373, LN-229, SW1088, Hs683, HFU251, SNB19, T98G, 1228 and 802 | ∆ miR-1908: ↓ Proliferation, viability, invasion and sphere formation | Oncogenic | [7] |
Glioma | SPRY4/ RAF1 axis | U251 | ↑↑ miR-1908: ↑ proliferation, invasion and ↓ apoptosis | Oncogenic | [8] |
Nasopharyngeal carcinoma | – | P109CD4 + TIL and P125CD8 + TIL cell lines | Hsa-miR-1908 was found to be over-expressed in TW03 (EBV +) or TW03 (EBV −) cells | – | [10] |
Non-small cell lung cancer | AKT1S1 and RP-p53 pathway | HBE, SK-MES-1, A549 and NCI-H460 | ↑↑ miR-1908: ↓ Proliferation via targeting AKT1S1 ∆ miR-1908: ↑ Proliferation | Tumor suppressor | [9] |
Osteosarcoma | SRSF3/miR-1908-5p/NKIRAS2 axis and NF-κB pathway | U2OS | ↑↑ miR-1908–5: ↑ proliferation, migration, and invasion via targeting NKIRAS2 ↑↑ NF-κB pathway: ↑ expression of miR-1908-5p ∆ SRSF3: ↓ expression of miR-1908-5p via blocking transactivation of NF-κB | Oncogenic | [11] |
PTEN | 143B, U-2 OS, MG-63 and Saos-2, and hFOB 1.19 | ↑↑ miR-1908–5: ↑ proliferation, migration, and invasion | Oncogenic | [12] | |
Ovarian cancer | – | A2780, and SK‐OV‐3 | ↑↑ miR-1908–5: ↓ cell viability | Tumor suppressor | [13] |
Prostate cancer | SRM | 22Rv1, PC3 and PC‐3 M‐luc‐C6 | miR-1908/ SRM axis could control secretion of EVs in prostate cancer | – | [14] |