Table 2 Function of miR-1908 in non-malignant disorders based on studies in cell lines (∆: knock-down or deletion SD: Sprague–Dawley, RA: Rheumatoid arthritis, NPCs: neural progenitor cells)
From: miR-1908: a microRNA with diverse functions in cancers and non-malignant conditions
Disease type | Interactions | Cell lines | Function | References |
|---|---|---|---|---|
Bipolar disorder | DLGAP4, GRIN1, STX1A, CLSTN1 and GRM4 | control and bipolar patient iPS cell lines | Valproate: ↑ miR-1908-5p expression in normal NPCs and ↓ miR-1908-5p expression in NPCs of patients with bipolar disorder | [15] |
Myocardial infarction | TGF-β1 and Smad2/3 | Cardiac fibroblasts from SD neonatal rats | miR-1908 was found to inhibit the Smad2/3 expression via targeting TGF-β1 | [16] |
Obesity | – | hMADS cells and HPA-v | ↑↑ miR-1908: ↑ proliferation and ↓ adipogenic differentiation A high level of miR-1908 was observed during the adipogenesis | [17] |
Obesity | IL-6, TNF-α, leptin and resistin | Human visceral preadipocytes | Levels of miR-1908 expression were found to be increased during the differentiation of human preadipocytes into adipocytes, and be regulated by adipokines | [18] |
Renal fibrosis | TGF-β1, smad2/3 and MMP-2 | Human primary renal interstitial cells | ↑↑ miR-1908: ↓ expressions of TGF-β1, smad2/3 and MMP-2, and ↓ renal fibrosis process | [19] |
Rheumatoid arthritis | HOTTIP/miR-1908–5p/ STAT3 axis | Rheumatoid arthritis synovial fibroblasts | ↑↑ HOTTIP (which sponges miR-1908): ↑ inflammation in RA | [20] |
Scar formation post-burn wound healing | Ski | Tissues from the dermis of six patients with hypertrophic scars | ↑↑ miR-1908: ↑ fibrosis and scar formation ∆ miR-1908: ↓ fibrosis and inflammation | [21] |