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Fig. 2 | Cancer Cell International

Fig. 2

From: Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway

Fig. 2

Resveratrol could activate the PI3K/AKT pathway [25]. On the other hand, this mentioned pathway could increase the Nrf2 translocation, finally induce transcription of anti-oxidative enzymes involved in inhibiting apoptosis. Moreover, GSK-3β could inhibit the Nrf2-ARE, then the transcription of antioxidant enzymes is induced. Interestingly, resveratrol by inactivating JAK-STAT or the NF-kB pathways could decrease ROS production and cell death [34, 35]

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Cancer Cell International

ISSN: 1475-2867

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