Table 8 Impact of resveratrol on the expression of genes in the context of cancers of the reproductive system
Type of cancer | Dose range | Cell line | Target | Pathway | Function | Refs. |
|---|---|---|---|---|---|---|
In vivo studies | ||||||
Prostate Cancer (PCa) | 50 mg/kg 5–100 μM, | DU145, PC3M, 293 T | MTA1, HDAC, ERK1/2, HDAC1, HDAC2, Lamin-A, myc, Flag | PTEN, AKT | RVT by regulating the PTEN/AKT pathway via inhibiting the MTA1/HDA unit could affect the progression and survival pathways of prostate cancer | [76] |
In vitro studies | ||||||
PCa | 25–200 μM | LNCaP, RWPE-1, LNCaP-B | ARV7, Bax, Bcl-2, AR | PI3K/AKT | RVT via PI3K/AKT pathway and ARV7 could promote apoptosis in LNCaP prostate cancer cells | [79] |
PCa | 0–50 μM | PC-3 | E-cadherin, Vimentin, Bax, Bcl-2, Caspase-3/9 | PI3K/AKT | RVT via downregulating the PI3K/AKT pathway could suppress the EMT in PC-3 cells | [80] |
Ovarian Cancer | 50Â mM | PA-1, OVCAR3, MDAH2774, SKOV3, PBMC, RBC, OSE1, OSE2 | P70s6K, mTOR, 4EBP1, GLUT2, GLUT3, GLUT4, GLUT1 | AKT | RVT via AKT/GLUT1 axis could induce apoptosis in ovarian cancer cells by impairing glucose uptake | [77] |
Ovarian Cancer | 0‑200 μM | A2780, SKOV3 | Caspase-3 | Notch1/PTEN/AKT | RVT via notch1/PTEN/AKT signaling could induce cell death in ovarian cancer cells | [78] |