Table 1 Demographics and clinical characteristics of patients in the development and validation cohort
Characteristic | Development cohort | Validation cohort |
|---|---|---|
n = (183) | n = (78) | |
No. (%) or Mean ± sd | No. (%) or Mean ± sd | |
Gender | ||
 Male | 136 (74.32%) | 57 (73.08%) |
 Female | 47 (25.68%) | 21 (26.92%) |
Age (years) | 61.55 ± 12.20 | 62.71 ± 10.32 |
Smoking | ||
 Yes | 114 (62.30%) | 50 (64.10%) |
 No | 69 (37.70%) | 28 (35.90%) |
Alcohol drink | ||
 Yes | 57 (31.15%) | 21 (26.92%) |
 No | 126 (68.85%) | 57 (73.08%) |
BMI (kg/m2) | ||
 < 18.00 | 8 (4.37%) | 6 (7.69%) |
 18.00–24.00 | 84 (45.90%) | 30 (38.46%) |
 > 24.00 | 91 (49.73%) | 42 (53.85%) |
Number of nodules | ||
 ≤ 3 | 117(63.93%) | 52(66.67%) |
 > 3 | 66(36.07%) | 26(33.33%) |
TNM stagea | ||
 I | 44 (24.04%) | 28 (35.90%) |
 II | 33 (18.03%) | 13 (16.67%) |
 III | 48 (26.23%) | 25 (32.05%) |
 IV | 58 (31.70%) | 12 (15.38%) |
Treatment | ||
 Surgery | 99 (54.10%) | 49 (62.82%) |
 Chemotherapy | 84 (45.90%) | 29 (37.18%) |
WBC (109/L) | 7.78 ± 2.96 | 7.59 ± 2.77 |
Neutrophils (109/L) | 5.06 ± 2.65 | 4.97 ± 2.48 |
Lymphocyte (109/L) | 1.80 ± 0.73 | 1.83 ± 0.61 |
Monocyte (10 9/L) | 0.93 ± 3.00 | 0.57 ± 0.25 |
Platelet (10 9/L) | 246.01 ± 102.92 | 227.88 ± 86.42 |
HGB (g/L) | 134.19 ± 21.81 | 136.37 ± 17.88 |
NLR | 3.28 ± 2.70 | 3.01 ± 1.63 |
RBC (10 9/L) | 4.58 ± 0.70 | 4.57 ± 0.63 |
LMR | 3.29 ± 1.57 | 3.66 ± 1.65 |
PLR | 153.56 ± 84.48 | 137.95 ± 70.84 |
APTT (s) | 28.12 ± 5.00 | 27.7 ± 4.16 |
Fbg (g/L) | 3.71 ± 1.29 | 3.35 ± 0.97 |
PT (s) | 11.98 ± 1.28 | 12.98 ± 12.53 |
TT (s) | 18.63 ± 1.53 | 18.62 ± 1.55 |
TP (g/L) | 73.21 ± 6.95 | 73.42 ± 5.48 |
ALB (g/L) | 40.60 ± 5.45 | 42.42 ± 4.21 |
ALP (U/L) | 152.07 ± 127.84 | 154.43 ± 245.92 |
ALT (U/L) | 59.30 ± 198.73 | 48.51 ± 59.70 |
AST (U/L) | 68.71 ± 162.13 | 58.86 ± 97.39 |
SLR | 1.48 ± 0.94 | 1.36 ± 1.01 |
CRE (μmol/L) | 72.85 ± 20.27 | 71.16 ± 19.11 |
CRP (mg/L) | 24.58 ± 41.53 | 17.38 ± 32.88 |
CHO (mmol/L) | 5.23 ± 2.38 | 5.87 ± 8.84 |
APOA (g/L) | 1.16 ± 0.35 | 1.42 ± 1.75 |
APOB (g/L) | 1.03 ± 0.38 | 0.97 ± 0.28 |
ABR | 1.28 ± 0.60 | 1.64 ± 2.34 |
LDH (U/L) | 263.24 ± 224.22 | 250.79 ± 209.46 |
LDL (mmol/L) | 3.35 ± 1.79 | 3.13 ± 1.19 |
HDL (U/L) | 1.16 ± 0.43 | 1.20 ± 0.32 |
AI (g/L) | 4.01 ± 2.99 | 3.87 ± 5.66 |
LHR | 3.20 ± 1.97 | 2.72 ± 1.08 |
Cys-C (mg/L) | 1.03 ± 0.22 | 0.99 ± 0.24 |
CEA (ng/mL) | 117.03 ± 1364.80 | 13.56 ± 65.19 |
AFP (ng/mL) | 11,851.07 ± 31,860.00 | 8482.72 ± 28,890.22 |
CA199 (U/mL) | 201.12 ± 1507.19 | 411.82 ± 2134.85 |
PNI | 49.61 ± 7.37 | 51.59 ± 5.94 |