Fig. 6
From: Cirsiliol regulates mitophagy in colon cancer cells via STAT3 signaling
Overexpression of STAT3 promotes mitophagy suppressed by cirsiliol in HCT116 cells. HCT116 cells were transfected with control plasmid or STAT3 overexpression plasmid (oeSTAT3) for 48 h and incubated with cirsiliol for another 24 h. A Representative western blot images of p-STAT3, total STAT3 and mitophagy proteins. B–G Quantitation of p-STAT3 (B), STAT3 (C), PINK1 (D), Parkin (E), BNIP3 (F), FUNDC1 (G). n = 3 per group. Data represent means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001 vs ctrl. #P < 0.05, ##P < 0.01, ###P < 0.001 vs cirsiliol without oeSTAT3