Fig. 9

The association between survival-related IRCGS and expression profile of immune checkpoints and immunotherapy efficacy. A–F the transcriptional expression profile of most immune checkpoints was significantly increased in the key IRCGS high-expressed group from TCGA and ICGC datasets. G, H The co-expressed correlation of key IRCGS and immune checkpoints was presented. I The IRCGS including VAV1, RHOA, and ZC3HAV1, was correlated to the immunotherapy response from diverse immunotherapeutic datasets in TIDE database. All *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns: no significance