STING pathway contributes to the prognosis of hepatocellular carcinoma and identification of prognostic gene signatures correlated to tumor microenvironment

Table 1 The correlation of sixteen immune-related gene markers and immune cell infiltration within various subtypes in the HCC cohort from TCGA database

Genes	Tumor purity			CD8 + T Cell		CD4 + T Cell		Macrophage		Neutrophil		Dendritic cell
Genes	R	P value		R	P value	R	P value	R	P value	R	P value	R	P value
SYK	− 0.504	****		0.610	****	0.545	****	0.739	****	0.576	****	0.785	****
ZC3HAV1	− 0.18	***		0.247	****	0.335	****	0.366	****	0.451	****	0.426	****
LYN	− 0.358	****		0.251	****	0.378	****	0.415	****	0.573	****	0.437	****
HCK	− 0.518	****		0.620	****	0.449	****	0.700	****	0.619	****	0.810	****
VAV1	− 0.529		****	0.690	****	0.456	****	0.669	****	0.580	****	0.795	****
PIK3CA	0.0358		0.507	0.245	****	0.392	****	0.436	****	0.532	****	0.370	****
CSK	− 0.181		***	0.254	****	0.508	****	0.481	****	0.399	****	0.450	****
NCK1	− 0.059		0.277	0.226	****	0.374	****	0.373	****	0.516	****	0.370	****
CD86	− 0.515		****	0.664	****	0.429	****	0.732	****	0.598	****	0.831	****
PPP3CA	− 0.081		0.132	0.257	****	0.398	****	0.414	****	0.481	****	0.382	****
TANK	0.017		0.758	0.235	****	0.385	****	0.373	****	0.509	****	0.319	****
FGFR1	− 0.399		****	0.300	****	0.449	****	0.485	****	0.391	****	0.408	****
CBL	− 0.152		**	0.328	****	0.573	****	0.526	****	0.559	****	0.518	****
CYBB	− 0.497		****	0.608	****	0.432	****	0.716	****	0.631	****	0.780	****
RHOA	− 0.0201		0.709	0.312	****	0.408	****	0.516	****	0.485	****	0.484	****
CBLB	− 0.096		0.007	0.366	****	0.421	****	0.444	****	0.538	****	0.468	****

R: Pearson’s correlation coefficient. All **P < 0.01, ****P < 0.001, *****P < 0.0001

ISSN: 1475-2867