Fig. 4

MDZ reduced tumour growth and increased the efficiency of the anti-PD-1 monoclonal antibody in a xenograft mouse model. A Procedures for establishing a subcutaneous tumour-bearing mouse model. PD-1 antibody was injected intraperitoneally twice a week 7 days after MDZ injection. Mice injected with PBS were the control. B Images of the subcutaneous tumours in the different groups (PBS, MDZ, α-PD-1, and α-PD-1 + MDZ). C, D The weights (C) and volumes (D) of the subcutaneous tumours in the indicated groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001