Fig. 1

Genetic and expression changes of the P-CA regulators in gastric cancer. A Mutation frequency of the P-CA regulators of gastric cancer patients in the TCGA cohort. B The CNV alteration frequency of each gene was obtained by statistical analysis of the copy number of P-CA regulators. The abscissa and the ordinate represent the P-CA-related gene and the mutation frequency, respectively. Red indicates an increase in copy number, and green indicates loss of copy number. C This circle diagram displayed the alterations sites of P-CA-related genes CNV on 23 chromosomes. D Boxplot shows the expression of P-CA regulators between tumor and normal tissues in the TCGA-GC cohort. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, p-value < 0.05 were considered statistically significant). TCGA, The Cancer Genome Atlas; CNV, copy number variation