A review on the role of mir-16-5p in the carcinogenesis

Ghafouri-Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Abdullah, Sara Tharwat; Taheri, Mohammad; Samadian, Mohammad

doi:10.1186/s12935-022-02754-0

Cancer Cell International

Table 2 Function of miR-16-5p or its partners in animal models (∆: knock-down or deletion)

From: A review on the role of mir-16-5p in the carcinogenesis

Tumor Type	Animal models	Results	Reference
Neuroblastoma	NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (NSG) mice	↑↑ miR-16-5p: ↓ bioluminescence, tumor size, and tumor weight	[7]
Neuroblastoma	BALB/c nude mice	∆ Circ-CUX1 (which suppresses miR-16-5p): ↓ tumor size, tumor weight, and tumor growth	[8]
Hepatocellular carcinoma	female BALB/c nude mice	↑↑ AGAP2-AS1: ↑ tumor growth and metastasis ∆ AGAP2-AS1: ↓ tumor growth and metastasis	[11]
	male Balb/c nude mice	∆ TTN-AS1 (which suppresses miR-16-5p): ↓ tumor size, tumor weight, sorafenib resistance	[13]
	male BALB/c nude mice	∆ SNHG22 (which suppresses the transcription of miR-16-5p): ↓ tumor growth and angiogenesis	[14]
Cervical cancer	BALB/c nude mice	∆ PDK4 (a target of miR-16-5p): ↑ chemotherapy efficiency	[16]
Cervical cancer	BALB/c nude mice	∆ DLX6-AS1 (which sponges miR-16-5p): ↓ tumor sizes, volumes, and weights	[25]
Breast cancer	BALB/c nude mice	∆ mir-16-5p: ↑ tumor volume, proliferation and metastasis	[17]
	nude mice	↑↑ mir-16-5p: ↓ tumor growth	[19]
	BALB/c nude mice	∆ ATXN8OS (which sponges miR-16-5p): ↑ tamoxifen sensitivity	[20]
Chordoma	BALB/c athymic nude mice	↑↑ mir-16-5p: ↓ tumor volume and proliferation	[27]
Chordoma	BALB/c nude mice	∆ LINC00662 (which sponges miR-16-5p): ↓ tumor volumes and tumor weight	[28]
Gastric cancer	BALB/c mice and NOD/SCID nude mice	M1 macrophage-secreted exosomes carrying miR-16-5p: ↓ tumor growth, volume and weight	[29]
Gastric cancer	female BALB/c nude mice	∆ LINC00649 (which sponges miR-16-5p): ↓ tumor growth	[31]
	female BALB/c-nude mice	∆ LINC00649 (which sponges miR-16-5p): ↓ tumor growth, tumor weight proliferation, and metastasis	[32]
Lung cancer	nude mice	∆ LINC00649 (which sponges miR-16-5p): ↓ tumor growth, volume and weight	[34]
Colorectal cancer	male BALB/c nude mice	↑↑ mir-16-5p: ↓ tumor volume and weight	[36]
	male nude mice	CuET treatment: ↓ tumor volume and growth, ↑ apoptosis	[37]
	BALB/c nude mice	↑↑ mir-16-5p: ↓ tumor volume and growth	[38]
Chondrosarcoma	male nude mice	↑↑ Resistin: vessel markers VEGF-A and CD31, EPC markers CD34 and CD133, and vessel formation	[42]
Bladder cancer	male BALB/c nude mice	↑↑ miR-16-5p: ↓ tumor volume, weight, and growth	[46]
Cholangiocarcinoma	female nude mice	↑↑ R-2HG (which increases levels of miR-16-5p) : ↓ tumor growth	[48]

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