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Fig. 7 | Cancer Cell International

Fig. 7

From: Human amniotic epithelial cells exert anti-cancer effects through secretion of immunomodulatory small extracellular vesicles (sEV)

Fig. 7

AD-sEV boosted the cytotoxicity of splenocytes to CT26 cells. BALB/c mice received either intact CT26 or CT26 cells treated with AD-sEV for 2 h before inoculation. Two weeks after cancer cell inoculation, the extent of cytotoxic responses of mice splenocytes against CT26 cells was tested and compared at different target: effector ratios by cAM assay. Each bar represents the percentage of increase in cell cytotoxicity in CT26-AD-sEV compared to CT26 group. Lower panel depicts comparative densities of cAM-labeled CT26 cells in the CT26-AD-sEV vs. CT26 group at different target: effector ratios. Error bars denote mean ± SD. Asterisks (*) indicate statistical significant differences (**p < 0.01, ****p < 0.0001). AD-sEV: AEC-derived extracellular vesicles

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Cancer Cell International

ISSN: 1475-2867

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